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The Race to Save Lives: Comparing Vaccine Development Timelines

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The Race to Save Lives: Vaccine Development Timelines

View the high-resolution of the infographic by clicking here.

Major advancements in medicine have led to a significant increase in average life expectancy, with vaccines being hailed as one of the most successful interventions to date.

In fact, the World Health Organization estimates that vaccines have prevented 10 million deaths between 2010 and 2015 alone. But while some were created and distributed in just over four months, others have taken over 40 years to develop. Then again, previous pandemics have petered out without any vaccine at all.

With approved COVID-19 vaccines soon to be distributed across the globe, the vaccine development process is being scrutinized by experts (and non-experts) the world over.

In the graphic above, we explore how long it has historically taken to bring a vaccine to market during pandemics dating back to the 1900s, and what the process entails.

Pandemic Vaccines of the Past

Although the assumption can be made that developing a vaccine for infectious diseases has become more efficient since the 1900s, that statement is not entirely correct.

It took approximately 25 years to develop a vaccine for the Spanish Flu which killed between 40-50 million people. Similarly, it was only last year that the FDA approved the first Ebola vaccine—an effort that took 43 years since the discovery of the virus.

But while scientists and medical experts have made headway in stopping major pandemics in their tracks, some of the worst outbreaks in history have yet to be cured.

Here is a closer look at the timeframes for vaccine development for every pandemic since the turn of the 20th century:

Name of Pandemic
Death TollTimeframe for Vaccine DevelopmentDuration
Spanish flu40-50 million1917-194225 years
H2N2 Asian flu1.1 millionFeb 1957-Jun 1957<5 months
H3N2 Hong Kong Flu1 millionJul 1968-Nov 1968<5 months
SARS774 (ongoing)2003-present17 years (ongoing)
Ebola11,3001976-201943 years
AIDS25-35 million (ongoing)1981-present39 years (ongoing)
H1N1 Swine Flu151,700 - 575,400Apr 2009-Sept 20096 months
MERS858 (ongoing)2012-present8 years (ongoing)
Coronavirus1.64 million (ongoing)Dec 2019-Nov 202011 months

When it comes to the speedy development of a COVID-19 vaccine, funding has played a vital role. With case numbers growing at an alarming rate, demand and urgency for a vaccine are high. In the U.S., the government paid Pfizer and BioNTech almost $2 billion for 100 million doses of a safe vaccine for COVID-19. This level of support from governments the world over means that pharmaceutical giants have less financial uncertainties to deal with compared to other vaccines.

Even though the global endeavor to distribute COVID-19 vaccines is now underway, many experts are concerned that the pace of approval could compromise long-term safety—but there are rigorous steps a vaccine must first go through before it is approved.

The Journey of a Vaccine Candidate

On average, it takes 10 years to develop a vaccine. According to the CDC, there are six stages involved in the process from start to finish:

  1. Exploratory stage: This stage typically consists of basic lab research that can last anywhere from 2 to 4 years.
  2. Pre-clinical stage: This stage uses tissue-culture or cell-culture systems and animal testing to give researchers an idea of how humans might respond to a candidate vaccine.
  3. Clinical development: Within the clinical development stage, there are three phases. Phase 1 examines the response of a small group of people to a candidate vaccine. Phase 2 involves giving the candidate vaccine to a larger group of people to study its safety, immunogenicity, proposed doses, schedule of immunizations, and method of delivery. In Phase 3, the vaccine is given to thousands of people to further test for efficacy and safety.
  4. Regulatory review and approval: National Regulatory Authorities are responsible for the approval of vaccines in different countries. For example, the U.S. Food and Drug Administration’s Center for Biologics Evaluation and Research (CBER) regulates all U.S. vaccines.
  5. Manufacturing: Typically, it can take anywhere from 6 to 36 months to produce, package, and deliver a high quality vaccine.
  6. Quality control: Different batches of a vaccine are continuously tested by different authorities around the world to ensure its ongoing safety.

Despite these lengthy timeframes, the COVID-19 vaccines and subsequent candidates have overturned the conventional process due to their unconventional technology.

Innovative Technologies Driving COVID’s Cure

Even though there are no approved vaccines for other coronaviruses such as MERS and SARS, previous research into these diseases has helped identify potential solutions for COVID-19 using messenger RNA (mRNA) technology.

“The mRNA vaccine platform technology [which the Pfizer/BioNTech vaccine uses] has been in development for over two decades.”

—Dr Zoltán Kis, Imperial College London.

The technology instructs our bodies to produce a small part of the COVID-19 virus called a spike protein. This triggers the immune system to make antibodies to fight against it and prepares the body for an actual COVID-19 infection.

Containing COVID-19 Batch-by-Batch

Deployment of a safe and effective vaccine could have the potential to save millions of lives and prevent infection for many more.

Although some experts have criticized the speed of vaccine candidate approvals, the quality will be closely monitored on a batch-by-batch basis.

With the COVID-19 crisis showing no signs of slowing down, most of us continue to live in hope that the light is at the end of the tunnel.

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Demographics

Charted: Global Tobacco Use by Country and Sex

This visual shows tobacco use by country and sex, highlighting which countries still have a high prevalence of smoking.

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Chart of tobacco use by country and sex in 2022

Charting Global Tobacco Use by Country and Sex

This was originally posted on our Voronoi app. Download the app for free on iOS or Android and discover incredible data-driven charts from a variety of trusted sources.

Globally, rates of tobacco use have been falling for decades. Today, it is estimated that one-in-five people around the world use tobacco products, according to data from the World Health Organization (WHO).

That’s still enough people to have a sizable impact on both global healthcare and the environment. And the prevalence of tobacco use by country, and by sex, varies widely.

This chart shows current tobacco use in selected countries around the world using WHO estimates for 2022.

Which People Smoke the Most?

Below we examine the entire dataset of global countries by 2022 tobacco use. Estimates are of people aged 15 years and older and include both smoked and smokeless tobacco (including vaping). Countries that had no data for 2022 have been omitted.

In almost every country, males use tobacco more than females. Globally, 36% of men are tobacco users compared to just 8% of women.

CountryTotal Prevalence (%)Male (%)Female (%)
🇦🇫 Afghanistan22.138.35.9
🇦🇱 Albania22.438.76.6
🇩🇿 Algeria21.641.90.7
🇦🇩 Andorra33.633.333.8
🇦🇷 Argentina23.128.218.1
🇦🇲 Armenia22.549.31.7
🇦🇺 Australia12.514.810.3
🇦🇹 Austria22.023.720.5
🇦🇿 Azerbaijan19.339.60.1
🇧🇸 Bahamas10.720.62.1
🇧🇭 Bahrain18.125.74.9
🇧🇩 Bangladesh31.148.914.2
🇧🇧 Barbados6.511.71.7
🇧🇾 Belarus27.947.212.0
🇧🇪 Belgium24.727.422.1
🇧🇿 Belize8.715.51.9
🇧🇯 Benin5.59.51.7
🇧🇹 Bhutan19.627.211.0
🇧🇴 Bolivia12.220.44.1
🇧🇦 Bosnia and Herzegovina35.141.029.5
🇧🇼 Botswana18.130.26.5
🇧🇷 Brazil12.315.79.1
🇧🇳 Brunei Darussalam17.131.32.2
🇧🇬 Bulgaria34.038.130.2
🇧🇫 Burkina Faso13.521.75.5
🇧🇮 Burundi10.015.25.0
🇨🇻 Cabo Verde10.516.25.0
🇰🇭 Cambodia16.127.35.5
🇨🇲 Cameroon5.610.21.1
🇨🇦 Canada11.413.79.2
🇹🇩 Chad6.812.31.4
🇨🇱 Chile28.230.625.8
🇨🇳 China24.947.32.0
🇨🇴 Colombia8.212.14.5
🇰🇲 Comoros16.226.26.2
🇨🇬 Congo15.028.22.0
🇨🇰 Cook Islands25.530.321.4
🇨🇷 Costa Rica8.813.24.5
🇨🇮 Cöte d'Ivoire8.616.40.7
🇭🇷 Croatia32.634.231.1
🇨🇺 Cuba18.526.910.4
🇨🇾 Cyprus34.046.022.1
🇨🇿 Czechia27.531.723.3
🇨🇩 Democratic Republic of the Congo11.119.92.6
🇩🇰 Denmark16.216.416.0
🇩🇴 Dominican Republic10.214.06.5
🇪🇨 Ecuador10.117.62.6
🇪🇬 Egypt24.748.90.3
🇸🇻 El Salvador8.315.61.9
🇪🇪 Estonia25.632.919.1
🇸🇿 Eswatini8.616.21.4
🇪🇹 Ethiopia4.67.81.4
🇫🇯 Fiji27.341.713.1
🇫🇮 Finland19.623.915.4
🇫🇷 France29.231.327.3
🇬🇲 Gambia9.618.70.6
🇬🇪 Georgia29.054.77.1
🇩🇪 Germany18.821.316.4
🇬🇭 Ghana3.15.90.3
🇬🇷 Greece29.633.126.3
🇬🇹 Guatemala12.022.71.7
🇬🇼 Guinea-Bissau7.514.80.6
🇬🇾 Guyana10.519.32.2
🇭🇹 Haiti7.312.62.3
🇭🇳 Honduras12.222.71.7
🇭🇺 Hungary29.434.724.5
🇮🇸 Iceland9.49.49.4
🇮🇳 India23.936.810.4
🇮🇩 Indonesia38.573.63.4
🇮🇷 Iran (Islamic Republic of)13.924.83.1
🇮🇶 Iraq18.736.01.6
🇮🇪 Ireland18.220.516.1
🇮🇱 Israel19.826.413.3
🇮🇹 Italy20.424.116.8
🇯🇲 Jamaica9.515.83.5
🇯🇵 Japan16.826.57.7
🇯🇴 Jordan36.357.813.4
🇰🇿 Kazakhstan21.738.26.9
🇰🇪 Kenya9.216.62.1
🇰🇮 Kiribati38.251.625.7
🇰🇼 Kuwait22.735.62.1
🇰🇬 Kyrgyzstan26.451.33.3
🇱🇦 Lao People's Democratic Republic25.843.28.4
🇱🇻 Latvia30.345.617.2
🇱🇧 Lebanon34.043.125.7
🇱🇸 Lesotho22.942.04.8
🇱🇷 Liberia7.112.51.7
🇱🇹 Lithuania27.940.117.3
🇱🇺 Luxembourg21.823.320.3
🇲🇬 Madagascar25.741.79.9
🇲🇼 Malawi7.113.01.7
🇲🇾 Malaysia22.643.80.7
🇲🇻 Maldives29.343.610.1
🇲🇱 Mali7.614.40.7
🇲🇹 Malta23.225.520.6
🇲🇭 Marshall Islands30.451.88.6
🇲🇷 Mauritania9.417.22.0
🇲🇺 Mauritius20.038.12.8
🇲🇽 Mexico14.623.16.9
🇲🇳 Mongolia29.352.67.3
🇲🇪 Montenegro32.130.933.2
🇲🇦 Morocco13.125.31.0
🇲🇲 Myanmar43.969.419.2
🇳🇦 Namibia12.521.34.7
🇳🇷 Nauru49.550.348.7
🇳🇵 Nepal24.942.79.4
🇳🇱 Netherlands (Kingdom of the)20.122.517.7
🇳🇿 New Zealand11.412.710.2
🇳🇪 Niger7.714.01.3
🇳🇬 Nigeria2.95.40.4
🇳🇴 Norway14.014.813.2
🇴🇲 Oman11.017.40.4
🇵🇰 Pakistan16.927.76.2
🇵🇼 Palau17.026.37.3
🇵🇦 Panama5.18.41.9
🇵🇬 Papua New Guinea40.455.424.9
🇵🇾 Paraguay10.617.43.8
🇵🇪 Peru7.011.62.6
🇵🇭 Philippines20.436.24.3
🇵🇱 Poland23.227.619.1
🇵🇹 Portugal20.927.115.5
🇶🇦 Qatar18.824.62.3
🇰🇷 Republic of Korea18.932.75.4
🇲🇩 Republic of Moldova27.852.76.3
🇷🇴 Romania27.537.418.5
🇷🇺 Russian Federation27.242.014.8
🇷🇼 Rwanda12.017.76.7
🇱🇨 Saint Lucia13.624.83.0
🇼🇸 Samoa22.231.013.2
🇸🇹 Sao Tome and Principe7.112.61.8
🇸🇦 Saudi Arabia17.428.42.1
🇸🇳 Senegal6.011.70.6
🇷🇸 Serbia36.638.834.6
🇸🇨 Seychelles20.834.65.7
🇸🇱 Sierra Leone11.417.35.5
🇸🇬 Singapore16.427.94.0
🇸🇰 Slovakia30.235.425.4
🇸🇮 Slovenia18.120.215.9
🇸🇧 Solomon Islands37.655.319.6
🇿🇦 South Africa20.335.16.5
🇪🇸 Spain24.927.522.5
🇱🇰 Sri Lanka19.137.82.4
🇸🇪 Sweden22.128.315.9
🇨🇭 Switzerland23.326.320.4
🇹🇭 Thailand18.937.71.8
🇹🇱 Timor-Leste37.664.59.8
🇹🇬 Togo5.610.20.9
🇹🇴 Tonga30.746.815.5
🇹🇳 Tunisia20.139.71.6
🇹🇷 Türkiye30.741.919.6
🇹🇲 Turkmenistan5.410.60.5
🇹🇻 Tuvalu33.848.319.0
🇺🇬 Uganda5.39.01.8
🇺🇦 Ukraine22.038.38.5
🇦🇪 United Arab Emirates11.715.52.5
🇬🇧 United Kingdom13.115.011.4
🇹🇿 United Republic of Tanzania7.513.12.2
🇺🇸 United States of America23.028.617.5
🇺🇾 Uruguay19.323.016.0
🇺🇿 Uzbekistan16.231.81.0
🇻🇳 Viet Nam22.844.32.2
🇾🇪 Yemen20.833.77.9
🇿🇲 Zambia12.021.82.7
🇿🇼 Zimbabwe9.219.00.8

From a regional perspective, we can see many countries in Europe and Asia have higher rates of tobacco use. Indonesia and Myanmar specifically have some of the highest tobacco use rates in the world, with 73.6% of Indonesian men estimated to smoke or use tobacco.

In many Asian countries we also see a greater difference between male and female smokers compared to the rest of the world. In China for example, 47.3% of males are estimated to use tobacco compared to just 2.0% of females.

On the other hand, the Americas and especially Africa have a lower prevalence of tobacco use. Nigeria at 2.9% had the lowest rate of tobacco use in the world in 2022.

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