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Visualizing How COVID-19 Antiviral Pills and Vaccines Work at the Cellular Level

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Current Strategies to Tackle COVID-19

Since the pandemic started in 2020, a number of therapies have been developed to combat COVID-19.

The leading options for preventing infection include social distancing, mask-wearing, and vaccination. They are still recommended during the upsurge of the coronavirus’s latest mutation, the Omicron variant.

But in December 2021, The United States Food and Drug Administration (USDA) granted Emergency Use Authorization to two experimental pills for the treatment of new COVID-19 cases.

These medications, one made by Pfizer and the other by Merck & Co., hope to contribute to the fight against the coronavirus and its variants. Alongside vaccinations, they may help to curb extreme cases of COVID-19 by reducing the need for hospitalization.

Despite tackling the same disease, vaccines and pills work differently:

VaccinesPills
Taken by injectionTaken by mouth
Used for prevention Used for treatment only
Create an enhanced immune system by stimulating antibody productionDisrupt the assembly of new viral particles

How a Vaccine Helps Prevent COVID-19

The main purpose of a vaccine is to prewarn the body of a potential COVID-19 infection by creating antibodies that target and destroy the coronavirus.

In order to do this, the immune system needs an antigen.

It’s difficult to do this risk-free since all antigens exist directly on a virus. Luckily, vaccines safely expose antigens to our immune systems without the dangerous parts of the virus.

In the case of COVID-19, the coronavirus’s antigen is the spike protein that covers its outer surface. Vaccines inject antigen-building instructions* and use our own cellular machinery to build the coronavirus antigen from scratch.

When exposed to the spike protein, the immune system begins to assemble antigen-specific antibodies. These antibodies wait for the opportunity to attack the real spike protein when a coronavirus enters the body. Since antibodies decrease over time, booster immunizations help to maintain a strong line of defense.

*While different vaccine technologies exist, they all do a similar thing: introduce an antigen and build a stronger immune system.

How COVID Antiviral Pills Work

Antiviral pills, unlike vaccines, are not a preventative strategy. Instead, they treat an infected individual experiencing symptoms from the virus.

Two drugs are now entering the market. Merck & Co.’s Lagevrio®, composed of one molecule, and Pfizer’s Paxlovid®, composed of two.

These medications disrupt specific processes in the viral assembly line to choke the virus’s ability to replicate.

The Mechanism of Molnupiravir

RNA-dependent RNA Polymerase (RdRp) is a cellular component that works similar to a photocopying machine for the virus’s genetic instructions. An infected host cell is forced to produce RdRp, which starts generating more copies of the virus’s RNA.

Molnupiravir, developed by Merck & Co., is a polymerase inhibitor. It inserts itself into the viral instructions that RdRp is copying, jumbling the contents. The RdRp then produces junk.

The Mechanism of Nirmatrelvir + Ritonavir

A replicating virus makes proteins necessary for its survival in a large, clumped mass called a polyprotein. A cellular component called a protease cuts a virus’s polyprotein into smaller, workable pieces.

Pfizer’s antiviral medication is a protease inhibitor made of two pills:

  1. The first pill, nirmatrelvir, stops protease from cutting viral products into smaller pieces.
  2. The second pill, ritonavir, protects nirmatrelvir from destruction by the body and allows it to keep working.

With a faulty polymerase or a large, unusable polyprotein, antiviral medications make it difficult for the coronavirus to replicate. If treated early enough, they can lessen the virus’s impact on the body.

The Future of COVID Antiviral Pills and Medications

Antiviral medications seem to have a bright future ahead of them.

COVID-19 antivirals are based on early research done on coronaviruses from the 2002-04 SARS-CoV and the 2012 MERS-CoV outbreaks. Current breakthroughs in this technology may pave the way for better pharmaceuticals in the future.

One half of Pfizer’s medication, ritonavir, currently treats many other viruses including HIV/AIDS.

Gilead Science is currently developing oral derivatives of remdesivir, another polymerase inhibitor currently only offered to inpatients in the United States.

More coronavirus antivirals are currently in the pipeline, offering a glimpse of control on the looming presence of COVID-19.

Author’s Note: The medical information in this article is an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. Please talk to your doctor before undergoing any treatment for COVID-19. If you become sick and believe you may have symptoms of COVID-19, please follow the CDC guidelines.

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United States

Mapped: Countries Where Recreational Cannabis is Legal

In total, only nine countries have fully legalized recreational cannabis use.

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This map shows the countries where recreational cannabis use is allowed as of April 2024.

Countries Where Recreational Cannabis is Legal

This was originally posted on our Voronoi app. Download the app for free on iOS or Android and discover incredible data-driven charts from a variety of trusted sources.

In 2024, Germany became the third European Union country to legalize cannabis for personal use, following Malta and Luxembourg.

Here, we map the countries where recreational cannabis use is allowed as of April 2024, based on data from Wikipedia.

Limited to Few Countries

In total, only nine countries have legalized recreational cannabis use nationwide. However, just a few of them have licensed sales.

CountryEffective dateLicensed sales since
🇺🇾 UruguayDecember 2013July 2017
🇬🇪 Georgia30 July 2018Never authorized
🇿🇦 South Africa18 September 2018Never authorized
🇨🇦 Canada17 October 201817 October 2018
🇲🇽 Mexico28 June 2021Never authorized
🇲🇹 Malta14 December 2021Never authorized
🇹🇭 Thailand9 June 20229 June 2022
🇱🇺 Luxembourg21 July 2023Never authorized
🇩🇪 Germany1 April 2024Never authorized
🇺🇸 U.S.Varies by stateVaries by state
🇦🇺 AustraliaVaries by jurisdictionNever authorized

At the federal level, cannabis is still considered an illegal substance in the United States. That said, individual states do have the right to determine their laws around cannabis sales and usage. Currently, cannabis is allowed in 24 states, 3 territories, and the District of Columbia.

Interestingly, the oldest legal text concerning cannabis dates back to the 1600s—when the colony of Virginia required every farm to grow and produce hemp.

Since then, cannabis use was fairly widespread until the 1930s when the Marihuana Tax Act was enforced, prohibiting marijuana federally but still technically allowing for medical use.

Today, the U.S. cannabis market is a $30 billion business. By the end of the decade, that number is expected to be anywhere from $58 billion to as much as $72 billion.

Similar to the U.S., Australia does not allow the use at the national level, but cannabis can be used legally in the Australian Capital Territory, which includes the capital Canberra.

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