Science

Every Vaccine and Treatment in Development for COVID-19, So Far

Published

3 years ago

April 1, 2020

Nick Routley

Every Vaccine and Treatment in Development for COVID-19, So Far

Every Vaccine and Treatment in Development for COVID-19

As the number of confirmed COVID-19 cases continues to skyrocket, healthcare researchers around the world are working tirelessly to discover new life-saving medical innovations.

The projects these companies are working on can be organized into three distinct groups:

Diagnostics: Quickly and effectively detecting the disease in the first place
Treatments: Alleviating symptoms so people who have disease experience milder symptoms, and lowering the overall mortality rate
Vaccines: Preventing transmission by making the population immune to COVID-19

Today’s graphics provide an in-depth look at who’s in the innovation race to defeat the virus, and they come to us courtesy of Artis Ventures, a venture capital firm focused on life sciences and tech investments.

Editor’s note: R&D is moving fast on COVID-19, and the situation is quite fluid. While today’s post is believed to be an accurate snapshot of all innovations and developments listed by WHO and FDA as of March 30, 2020, it is possible that more data will become available.

Knowledge is Power

Testing rates during this pandemic have been a point of contention. Without widespread testing, it has been tough to accurately track the spread of the virus, as well as pin down important metrics such as infectiousness and mortality rates. Inexpensive test kits that offer quick results will be key to curbing the outbreak.

Here are the companies and institutions developing new tests for COVID-19:

covid-19 diagnostics in development

The ultimate aim of companies like Abbott and BioFire Defense is to create a test that can produce accurate results in as little as a few minutes.

In the Trenches With Coronavirus

While the majority of people infected with COVID-19 only experience minor symptoms, the disease can cause severe issues in some cases – even resulting in death. Most of the forms of treatment being pursued fall into one of two categories:

Treating respiratory symptoms – especially the inflammation that occurs in severe cases
Antiviral growth – essentially stopping viruses from multiplying inside the human body

Here are the companies and institutions developing new treatment options for COVID-19:

covid-19 treatment in development

A wide range of players are in the race to develop treatments related to COVID-19. Pharma and healthcare companies are in the mix, as well as universities and institutes.

One surprising name on the list is Fujifilm. The Japanese company’s stock recently shot up on the news that Avigan, a decades-old flu drug developed through Fujifilm’s healthcare subsidiary, might be effective at helping coronavirus patients recover. The Japanese government’s stockpile of the drug is reportedly enough to treat two million people.

Vaccine

The progress that is perhaps being watched the closest by the general public is the development of a COVID-19 vaccine.

Creating a safe vaccine for a new illness is no easy feat. Thankfully, rapid progress is being made for a variety of reasons, including China’s efforts to sequence the genetic material of Sars-CoV-2 and to share that information with research groups around the world.

Another factor contributing to the unprecedented speed of development is the fact that coronaviruses were already on the radar of health science researchers. Both SARS and MERS were caused by coronaviruses, and even though vaccines were shelved once those outbreaks were contained, learnings can still be applied to defeating COVID-19.

covid-19 vaccines in development

One of the most promising leads on a COVID-19 vaccine is mRNA-1273. This vaccine, developed by Moderna Therapeutics, is being developed with extreme urgency, skipping straight into human trials before it was even tested in animals. If all goes well with the trials currently underway in Washington State, the company hopes to have an early version of the vaccine ready by fall 2020. The earliest versions of the vaccine would be made available to at-risk groups such as healthcare workers.

Further down the pipeline are 15 types of subunit vaccines. This method of vaccination uses a fragment of a pathogen, typically a surface protein, to trigger an immune response, teaching the body’s immune system how to fight off the disease without actually introducing live pathogens.

No Clear Finish Line

Unfortunately, there is no silver bullet for solving this pandemic.

A likely scenario is that teams of researchers around the world will come up with solutions that will incrementally help stop the spread of the virus, mitigate symptoms for those infected, and help lower the overall death toll. As well, early solutions rushed to market will need to be refined over the coming months.

We can only hope that the hard lessons learned from fighting COVID-19 will help stop a future outbreak in its tracks before it becomes a pandemic. For now, those of us on the sideline can only do our best to flatten the curve.

Related Topics:coronavirus treatments testing kits covid-19 coronavirus vaccine subunit vaccines

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Misc

Visualizing the Biomass of All the World’s Mammals

When the world’s biomass—the stuff we’re made of—is tallied up, humans and cattle outweigh wild mammals by a massive margin.

Published

1 month ago

April 28, 2023

Nick Routley

Visualizing the Biomass of All the World’s Mammals

Even as we understand more about the world we live in, certain aspects of it remain undefined or hard to comprehend.

One such example is in the scale and distribution of Earth’s life. What’s the ratio of wild to domesticated animals? How much do all of the world’s humans weigh?

Until recently, such questions were nearly unanswerable. A new report titled The Global Biomass of Wild Mammals helps shed more light on the composition and scale of life on our planet. The research provides an estimate of the biomass of all mammals, globally—including humans.

So, What is Biomass Anyway?

Biomass is simply the weight of living things.

In this study, researchers

created rough estimates for four major categories of mammals: humans, domesticated animals, and those that were found in wild terrestrial and marine environments. A further breakdown of mammal groups are found within each category.

To achieve this, they took the estimated number of species from census data and multiplied it with each species’ average body mass.

One component worth pointing out is that animals contribute very different amounts to the world’s biomass total. For example, whales significantly outweigh rodents in terms of biomass, even though there are fewer species and populations of whales. The fact that whales are so much larger than rodents means that even smaller populations can contribute a meaningful portion to overall biomass.

Mammalian Biomass, Organized Neatly

Each larger cube above represents 20 million metric tons of carbon, and the entirety of the visualization represents all living mammalian life on Earth.

The paper separates mammals into four distinct categories:

Category	Total Mass (Mt)	Top Sub-Category
Domesticated Mammals	651	Cattle (416 Mt)
Humans	394	n/a
Wild Marine Mammals	40	Baleen Whales (23 Mt)
Wild Terrestrial Mammals	24	Even-Hoofed Mammals (11 Mt)
Total	1,109

One of the most obvious takeaways from this data is that humans make up one-third of total mammalian biomass.

Perhaps even more strikingly, the animals we’ve domesticated for food, companionship, and labor make up close to 60% of the total weight of Earth’s mammals. Domesticated dogs and cats alone equal the total weight of all other wild land mammals combined.

The world’s sheep, on their own, weigh as much as all the whales and seals in the ocean. Domesticated buffalo such as the water buffalo, a species commonly found in Asia, combine to have the third largest biomass of all mammals.

Finally, there’s one category of mammal that comes way out on top.

Cattle Planet

The global livestock population has risen along with the human population, and cattle are now the top mammal in the world by weight.

In fact, just the United States’ share of cattle matches the biomass of all wild mammals on Earth.

As the standard of living continues to rise for people around the world, beef consumption has been increasing in many developing countries. Of course, raising cattle is a resource and land intensive operation, and there have been very real impacts on a global scale. For one, cows are a major source of methane emissions. As well, in Brazil, which accounts for around 25% of the world’s cattle population, pasture has directly replaced large swaths of rainforest habitat.

Waning Wildlife

At the very bottom of the visualization, dwarfed by humans and domesticated mammals, lies the vast array of wild mammals that live on planet Earth.

It’s sobering to see that the biomass of North America’s human population alone compares closely with that of all terrestrial wild mammals in the world. This includes plentiful creatures like rats and mice, as well as large mammals like elephants and bears.

Below are the top 10 wild mammalian contributors to biomass in the natural world.

Rank	Contributor	Total Mass (Mt)	Individuals (millions)
#1	Fin Whales	8	0.1
#2	Sperm Whales	7	0.4
#3	Humpback Whales	4	0.1
#4T	Antarctic Minke Whales	3	0.5
#4T	Blue Whales	3	0.05
#6	White-Tailed Deer	2.7	45
#7	Crabeater Seals	2.0	10
#8	Wild Boar	1.9	30
#9T	African Elephants	1.3	0.5
#9T	Bryde's Whales	1.3	0.1

In the ocean, whales and seals are the heavyweight champions. On land, deer, and boar come out on top as they are both heavy and plentiful.

Humans have a complicated relationship with large mammals. We feel a very clear connection to these creatures, and they are often the key figures in conservation efforts. That said, even small populations of humans have wiped out large mammal species in the past.

The news that cattle outweigh wild land animals by a factor of 20:1 is a reminder that human influence is perhaps even more powerful than we think.

The more we’re exposed to nature’s full splendor […] the more we might be tempted to imagine that nature is an endless and inexhaustible resource. In reality, the weight of all remaining wild land mammals is less than 10% of humanity’s combined weight. – Ron Milo, Professor of Systems Biology

Where does this data come from?

Source: The global biomass of wild mammals

Data notes: To come up with the numbers above, scientists estimated the total biomass of wild mammals on Earth by manually collecting population estimates for 392 land mammal species, which make up about 6% of all wild land mammal species, and using machine learning to infer the global populations of the remaining 94%. Their estimate includes 4,805 wild land mammal species out of approximately 6,400 known and extant wild land mammal species, excluding low-abundance species for which data are scarce.