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As of May 27, 2021, COVID has claimed the lives of almost 3.5 million people worldwide
That’s 0.04% of the global population
We’ll be updating this graphic as the current pandemic continues
Visualizing the World’s Deadliest Pandemics
Humanity has been battling against disease for centuries.
And while most contagious outbreaks have never reached full-blown pandemic status, there have been several times throughout history when a disease has caused mass devastation.
Here’s a look at the world’s deadliest pandemics to date, viewed from the lens of the impact they had on the global population at the time.
Editor’s note: The above graphic was created in response to a popular request from users after viewing our popular history of pandemics infographic initially released a year ago.
Death Toll, by Percent of Population
In the mid-1300s, a plague known as the Black Death claimed the lives of roughly 200 million people—more than 50% of the global population at that time.
Here’s how the death toll by population stacks up for other significant pandemics, including COVID-19 so far.
Pandemic
Death Toll by % of Population
Year of Population Estimate
Black Death
51.0%
1300
Plague of Justinian
19.1%
500
Smallpox
12.1%
1500
Antonine Plague
2.6%
200
Spanish Flu
2.5%
1919
The Third Plague
1.0%
1850
HIV/AIDS
0.7%
1981
COVID-19
0.04%
2021 (as of May 27)
The specific cause of the Black Death is still up for debate. Many experts claim the 14th-century pandemic was caused by a bubonic plague, meaning there was no human-to-human transmission, while others argue it was possibly pneumonic.
Interestingly, the plague still exists today—however, it’s significantly less deadly, thanks to modern antibiotics.
History Repeats, But at Least We Keep Learning
While we clearly haven’t eradicated infection diseases from our lives entirely, we’ve at least come a long way in our understanding of what causes illness in the first place.
In ancient times, people believed gods and spirits caused diseases and widespread destruction. But by the 19th century, a scientist named Louis Pasteur (based on findings by Robert Koch) discovered germ theory—the idea that small organisms caused disease.
What will we discover next, and how will it impact our response to disease in the future?
Source:CDC, WHO, Johns Hopkins University, Encyclopedia Britannica, Historical Records Notes: Many of the death toll numbers are best estimates based on available research. Some, such as the Plague of Justinian, are subject to debate based on new evidence