More than $100 billion is spent worldwide every year in the quest to cure cancer. However, despite this exhaustive effort, the number of cancer cases is estimated to increase by 70% over the next two decades, and is expected to reach 25 million new cases per year by 2030.
Is there a prospect of stopping – or even slowing – the spread of this debilitating disease?
What You Need to Know About Cancer
The below infographic from Healthgrad shows that although there have been huge advancements in the understanding of how cancers behave and the development of more effective treatments, there is still no single “cure” for cancer.
That said, there are some very promising advances in cancer treatment in progress, and we highlight some thoughts on gaining exposure to these companies later on in the article.
A Global Epidemic
As the infographic points out, we all have cancer cells in our bodies, which our immune systems are responsible for fighting off. Problems arise when these cells are triggered by certain external and internal factors, such as exposure to environmental toxins, viruses, or the natural process of aging.
Once these cancer cells are triggered, they begin to multiply rapidly and overwhelm the immune system.
No Single Cure
Cancer is not a single disease, so there can be no single cure. There are actually more than 100 different forms of verified cancerous diseases, however some sources claim this number is much higher.
New discoveries about the onset and behavior of cancer are being made all the time, and they are leading to the development of more effective therapies. For example, it was recently discovered that there are multiple subtypes of breast cancer, which may occur at the same time within a patient and have various degrees of responsiveness to different treatments.
Findings such as this are driving new forms of more personalized diagnostic and treatment methods, such as vaccines, immunotherapy products, and targeted therapies.
How to Invest in a Cure for Cancer
1.) Prepare to be patient:
Currently we are seeing a shift in medical innovation, whereby smaller biotech companies are producing game-changing breakthrough treatments in relatively new fields of oncology such as targeted immunotherapy. Investing in these smaller biotech companies can produce huge returns, but the risk is also high. If a promising biotech startup doesn’t end up getting its product approved by the FDA, the stock price will likely plummet.
Another point to keep in mind is that these stocks tend to be quite volatile along the road to marketability. Patience is a virtue when it comes to investing in pharmaceutical companies, and it can take stocks up to five or ten years to reach their full potential.
2.) Diversify among therapies:
Today, large pharmaceutical companies are bringing the latest cancer therapy products to market, while smaller biotech companies are working on the next wave of innovative new cancer therapies.
A good strategy is to diversify investments by seeking opportunities in both the current and future waves of cancer treatment innovation. Bear in mind that many big pharma companies are actively acquiring smaller biotechs and will continue to do so over the coming years.
3.) Opportunities in acquisitions:
In recent years, corporate interest in startups that are developing cancer therapies has been increasing.
According to CB Insights, corporate-backed deals in cancer-focused startups increased from around 30 in 2012 to nearly 50 in 2016 (as of October 2016). And it’s not just big pharma that’s taken notice: tech companies such as Google and IBM have entered this space recently, investing millions into startups developing immune-oncology and targeted therapy treatments.
Among the most notable deals:
- Biopharma company Celgene has been the most active investor in cancer therapy startups, backing 16 companies in the last five years including Cleave Biosciences ($37 million Series B round) and Quanticel Pharmaceuticals ($485 million acquisition) in 2015.
- Pharma company AbbVie acquired Stemcentrx for $10.2 billion in Q2 2016, one of the largest acquisitions of a VC-backed company in history.
- Drug development startup Petra Pharma was backed by five of the top corporate investors in a $48 million Series A round, including AbbVie Biotech Ventures, Eli Lilly & Co, Johnson & Johnson Innovation, Pfizer Venture Investments, and WuXi PharmaTech – as well as IBM Watson Group.
Preventive vs. Curative
Most cancers, once diagnosed, cost hundreds of thousands of dollars to treat. Many health care professionals in the field of oncology have argued that the way money is currently spent on cancer treatment is not sustainable. Their stance is that more funding should be allocated to preventive rather than curative measures. For example, granting widespread access to vaccinations against certain prevalent cancers – such as for Hepatitis B, the leading cause of liver cancer, and for HPV, the leading cause of cervical cancer – could go a long way to preventing the onset of this devastating disease.
Mapped: The Fastest (and Slowest) Internet Speeds in the World
Internet speeds vary depending on your location. Here’s a look at the countries with the fastest—and slowest—internet speeds worldwide.
Mapped: The World’s Fastest (and Slowest) Internet Speeds
How quickly did this page load for you?
The answer depends on the device you’re using, and where in the world you’re located. Average internet speeds vary wildly from country to country.
Which countries have the fastest internet connection? Using data from the Speedtest Global Index™, this map ranks the fastest (and slowest) internet speeds worldwide, comparing both fixed broadband and mobile.
What Factors Affect Internet Speed?
Before diving in, it’s important to understand the key factors that impact a country’s internet speed. Generally speaking, internet speed depends on:
- Infrastructure or the type of cabling (copper or fiber-optic) that a country’s utilizing to support their internet service. Typically, the newer the infrastructure, the faster the connection.
- Proximity/connection to submarine cables is important, as these massive undersea fiber-optic cables transmit about 97% of the world’s communication data.
- The size of a country, since landmass affects how much it costs to upgrade infrastructure. The smaller the country, the cheaper it is to upgrade cabling.
- Investment makes a difference, or how much a country’s government prioritizes internet accessibility.
Of course, other factors may influence a country’s internet speed too, such as government regulation and intentional bandwidth throttling, which is the case in countries like Turkmenistan.
Ranked: Fixed Broadband Internet Speeds
The Speedtest Global Index uses data from hundreds of millions of people, in more than 190 countries, to measure both fixed broadband and mobile connections.
When it comes to the fastest fixed broadband, Singapore comes in first place, with a download speed of 262.2 mbps—more than double the global average.
|#||Country||Global Speed (Mbps)|
|2||🇭🇰 Hong Kong||254.4|
|7||🇰🇷 South Korea||216.7|
|12||🇺🇸 United States||199|
|13||🇦🇪 United Arab Emirates||195.11|
|20||🇲🇴 Macau (SAR)||170.84|
|23||🇳🇿 New Zealand||164.16|
|40||🇸🇲 San Marino||114.24|
|47||🇬🇧 United Kingdom||95.79|
|51||🇸🇦 Saudi Arabia||91.65|
|52||🇹🇹 Trinidad and Tobago||87.42|
|74||🇨🇷 Costa Rica||57.27|
|76||🇧🇸 The Bahamas||55.89|
|78||🇿🇦 South Africa||53.6|
|80||🇻🇨 Saint Vincent and the Grenadines||50.8|
|84||🇱🇨 Saint Lucia||49.5|
|90||🇧🇦 Bosnia and Herzegovina||43.1|
|91||🇲🇭 Marshall Islands||42.6|
|98||🇲🇰 North Macedonia||38.84|
|101||🇨🇮 Côte d'Ivoire||35.41|
|109||🇰🇳 Saint Kitts and Nevis||32.78|
|110||🇩🇴 Dominican Republic||31.85|
|116||🇸🇻 El Salvador||26.41|
|119||🇱🇰 Sri Lanka||26.05|
|123||🇧🇫 Burkina Faso||25.52|
|126||🇨🇬 Congo (Brazzaville)||24.12|
|128||🇪🇭 Western Sahara||23.84|
|130||🇨🇻 Cape Verde||23.78|
|139||🇲🇲 Republic of the Union of Myanmar||19.78|
|146||🇦🇬 Antigua and Barbuda||17.11|
|152||🇵🇬 Papua New Guinea||16.4|
|163||🇬🇶 Equatorial Guinea||12.17|
|164||🇸🇱 Sierra Leone||12.13|
|165||🇨🇩 DR Congo||11.46|
|169||🇸🇿 Swaziland (Eswatini)||10.62|
|172||🇬🇲 The Gambia||10.09|
Size could be a factor in Singapore’s speedy internet, as it’s one of the smallest
and also densest countries in the world. With a landmass of just 280 square miles, it’s around the same size as Austin, Texas.
The country’s government has also prioritized investment in digital infrastructure, especially in recent years. In 2020, the Singaporean government promised to invest $2.52 billion towards digital innovation, with a portion dedicated to upgrading the country’s telecom infrastructure.
At the opposite end of the spectrum, Cuba has the slowest fixed broadband, with a speed of 3.46 mbps. Along with poor government funding, Cuba also has limited access to submarine cables. While most countries are connected to several, Cuba is only connected to one.
Ranked: Mobile Internet Speeds
Mobile internet uses cell towers to wirelessly transmit internet to your phone. Because of this extra element, the ranking for mobile internet speeds varies from fixed broadband.
|#||Country||Global Speed (Mbps)|
|1||🇦🇪 United Arab Emirates||195.52|
|2||🇰🇷 South Korea||192.16|
|6||🇸🇦 Saudi Arabia||149.95|
|17||🇺🇸 United States||96.31|
|23||🇬🇧 United Kingdom||80.82|
|25||🇭🇰 Hong Kong||78.75|
|27||🇳🇿 New Zealand||73.17|
|34||🇲🇴 Macau (SAR)||62.43|
|42||🇲🇰 North Macedonia||57.37|
|47||🇿🇦 South Africa||50.44|
|66||🇹🇹 Trinidad and Tobago||37.54|
|70||🇧🇦 Bosnia and Herzegovina||34.97|
|72||🇨🇷 Costa Rica||34.39|
|78||🇧🇸 The Bahamas||32.63|
|85||🇩🇴 Dominican Republic||31.07|
|93||🇲🇲 Republic of the Union of Myanmar||27.94|
|99||🇸🇻 El Salvador||25.17|
|125||🇨🇮 Côte d'Ivoire||18.37|
|130||🇱🇰 Sri Lanka||16.02|
The United Arab Emirates (UAE) is first on the list, with a download speed of 195.5 mbps. Not only is mobile data fast in the UAE, it’s also relatively cheap, compared to other countries on the ranking. The average cost of 1 GB of data in the UAE is around $3.78, while in South Korea (#2 on the list) it’s $10.94.
The Future is 5G
Innovation and new technologies are changing the digital landscape, and things like 5G networks are becoming more mainstream across the globe.
Because of the rapidly changing nature of this industry, the data behind this ranking is updated monthly to provide the latest look at internet speeds across the globe.
This means the bar is gradually raising when it comes to internet speed, as faster, stronger internet connections become the norm. And countries that aren’t equipped to handle these souped-up networks will lag behind even further.
Ranked: Big Tech CEO Insider Trading During the First Half of 2021
Big Tech is worth trillions, but what are insiders doing with their stock? We breakdown Big Tech CEO insider trading during the first half of 2021.
Big Tech CEO Insider Trading During The First Half of 2021
When CEOs of major companies are selling their shares, investors can’t help but notice.
After all, these decisions have a direct effect on the personal wealth of these insiders, which can say plenty about their convictions with respect to the future direction of the companies they run.
Considering that Big Tech stocks are some of the most popular holdings in today’s portfolios, and are backed by a collective $5.3 trillion in institutional investment, how do the CEOs of these organizations rank by their insider selling?
|CEO||Stock||Shares Sold H1 2021||Value of Shares ($M)|
|Jeff Bezos||Amazon (AMZN)||2.0 million||$6,600|
|Mark Zuckerberg||Facebook (FB)||7.1 million||$2,200
|Satya Nadella||Microsoft (MSFT)||278,694||$65|
|Sundar Pichai||Google (GOOGL)||27,000||$62|
|Tim Cook||Apple (AAPL)||0||$0|
Breaking Down Insider Trading, by CEO
Let’s dive into the insider trading activity of each Big Tech CEO:
During the first half of 2021, Jeff Bezos sold 2 million shares of Amazon worth $6.6 billion.
This activity was spread across 15 different transactions, representing an average of $440 million per transaction. Altogether, this ranks him first by CEO insider selling, by total dollar proceeds. Bezos’s time as CEO of Amazon came to an end shortly after the half way mark for the year.
In second place is Mark Zuckerberg, who has been significantly busier selling than the rest.
In the first half of 2021, he unloaded 7.1 million shares of Facebook onto the open market, worth $2.2 billion. What makes these transactions interesting is the sheer quantity of them, as he sold on 136 out of 180 days. On average, that’s $12 million worth of stock sold every day.
Zuckerberg’s record year of selling in 2018 resulted in over $5 billion worth of stock sold, but over 90% of his net worth still remains in the company.
Next is Satya Nadella, who sold 278,694 shares of Microsoft, worth $234 million. Despite this, the Microsoft CEO still holds an estimated 1.6 million shares, which is the largest of any insider.
Microsoft’s stock has been on a tear for a number of years now, and belongs to an elite trillion dollar club, which consists of only six public companies.
Fourth on the list is Sundar Pichai who has been at the helm at Google for six years now. Since the start of 2021, he’s sold 27,000 shares through nine separate transactions, worth $62.5 million. However, Pichai still has an estimated 6,407 Class A and 114,861 Class C shares.
Google is closing in on a $2 trillion valuation and is the best performing Big Tech stock, with shares rising 60% year-to-date. Their market share growth from U.S. ad revenues is a large contributing factor.
Last, is Tim Cook, who just surpassed a decade as Apple CEO.
During this time, shares have rallied over 1,000% and annual sales have gone from $100 billion to $347 billion. That said, Cook has sold 0 shares of Apple during the first half of 2021. That doesn’t mean he hasn’t sold shares elsewhere, though. Cook also sits on the board of directors for Nike, and has sold $6.9 million worth of shares this year.
Measuring Insider Selling
All things equal, it’s desirable for management to have skin in the game, and be invested alongside shareholders. It can also be seen as aligning long-term interests.
A good measure of insider selling activity is in relation to the existing stake in the company. For example, selling $6.6 billion worth of shares may sound like a lot, but when there are 51.7 million Amazon shares remaining for Jeff Bezos, it actually represents a small portion and is probably not cause for panic.
If, however, executives are disclosing large transactions relative to their total stakes, it might be worth digging deeper.
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