How Many People Die Each Day?
As the COVID-19 pandemic rages on, the media continues to rattle off statistics at full force.
However, without a frame of reference, numbers such as the death toll can be difficult to interpret. Mortalities attributed to the virus, for example, are often measured in the thousands of people per day globally—but is this number a little or a lot, relative to typical causes of death?
Today’s graphic uses data from Our World in Data to provide context with the total number of worldwide daily deaths. It also outlines how many people who die each day from specific causes.
Worldwide Deaths by Cause
Nearly 150,000 people die per day worldwide, based on the latest comprehensive research published in 2017. Which diseases are the most deadly, and how many lives do they take per day?
Here’s how many people die each day on average, sorted by cause:
|#4||Lower respiratory infections||7,010|
|#24||Alcohol use disorders||507|
|#25||Drug use disorders||456|
|#30||Heat (hot and cold exposure)||146|
|Total Daily Deaths||147,118|
Cardiovascular diseases, or diseases of the heart and blood vessels, are the leading cause of death. However, their prominence is not reflected in our perceptions of death nor in the media.
While the death toll for HIV/AIDS peaked in 2004, it still affects many people today. The disease causes over 2,600 daily deaths on average.
Interestingly, terrorism and natural disasters cause very few deaths in relation to other causes. That said, these numbers can vary from day to day—and year to year—depending on the severity of each individual instance.
Total Daily Deaths by Country
On a national level, these statistics vary further. Below are the total deaths from all causes for selected countries, based on 2017 data.
China and India both see more than 25,000 total deaths per day, due to their large populations.
However, with 34.7 daily deaths per million people each day, Russia has the highest deaths proportional to population out of any of these countries.
While these numbers help provide some context for the global scale of COVID-19 deaths, they do not offer a direct comparison.
The fact is that many of the aforementioned death rates are based on much larger and consistent sample sizes of data. On the flipside, since WHO declared COVID-19 a pandemic on March 11, 2020, daily confirmed deaths have fallen in a wide range between 272 and 10,520 per day—and there is no telling what could happen in the future.
On top of this variance, data on confirmed COVID-19 deaths has other quirks. For example, testing rates for the virus may vary between jurisdictions, and there have also been disagreements between authorities on how deaths should even be tallied in the first place. This makes getting an accurate picture surprisingly complicated.
While it’s impossible to know the true death toll of COVID-19, it is clear that in some countries daily deaths have reached rates 50% or higher than the historical average for periods of time:
Time, and further analysis, will be required to determine a more accurate COVID-19 death count.
Visualizing How COVID-19 Antiviral Pills and Vaccines Work at the Cellular Level
Despite tackling the same disease, vaccines and antiviral pills work differently to combat COVID-19. We visualize how they work in the body.
Current Strategies to Tackle COVID-19
Since the pandemic started in 2020, a number of therapies have been developed to combat COVID-19.
The leading options for preventing infection include social distancing, mask-wearing, and vaccination. They are still recommended during the upsurge of the coronavirus’s latest mutation, the Omicron variant.
But in December 2021, The United States Food and Drug Administration (USDA) granted Emergency Use Authorization to two experimental pills for the treatment of new COVID-19 cases.
These medications, one made by Pfizer and the other by Merck & Co., hope to contribute to the fight against the coronavirus and its variants. Alongside vaccinations, they may help to curb extreme cases of COVID-19 by reducing the need for hospitalization.
Despite tackling the same disease, vaccines and pills work differently:
|Taken by injection||Taken by mouth|
|Used for prevention||Used for treatment only|
|Create an enhanced immune system by stimulating antibody production||Disrupt the assembly of new viral particles|
How a Vaccine Helps Prevent COVID-19
The main purpose of a vaccine is to prewarn the body of a potential COVID-19 infection by creating antibodies that target and destroy the coronavirus.
In order to do this, the immune system needs an antigen.
It’s difficult to do this risk-free since all antigens exist directly on a virus. Luckily, vaccines safely expose antigens to our immune systems without the dangerous parts of the virus.
In the case of COVID-19, the coronavirus’s antigen is the spike protein that covers its outer surface. Vaccines inject antigen-building instructions* and use our own cellular machinery to build the coronavirus antigen from scratch.
When exposed to the spike protein, the immune system begins to assemble antigen-specific antibodies. These antibodies wait for the opportunity to attack the real spike protein when a coronavirus enters the body. Since antibodies decrease over time, booster immunizations help to maintain a strong line of defense.
*While different vaccine technologies exist, they all do a similar thing: introduce an antigen and build a stronger immune system.
How COVID Antiviral Pills Work
Antiviral pills, unlike vaccines, are not a preventative strategy. Instead, they treat an infected individual experiencing symptoms from the virus.
These medications disrupt specific processes in the viral assembly line to choke the virus’s ability to replicate.
The Mechanism of Molnupiravir
RNA-dependent RNA Polymerase (RdRp) is a cellular component that works similar to a photocopying machine for the virus’s genetic instructions. An infected host cell is forced to produce RdRp, which starts generating more copies of the virus’s RNA.
Molnupiravir, developed by Merck & Co., is a polymerase inhibitor. It inserts itself into the viral instructions that RdRp is copying, jumbling the contents. The RdRp then produces junk.
The Mechanism of Nirmatrelvir + Ritonavir
A replicating virus makes proteins necessary for its survival in a large, clumped mass called a polyprotein. A cellular component called a protease cuts a virus’s polyprotein into smaller, workable pieces.
Pfizer’s antiviral medication is a protease inhibitor made of two pills:
- The first pill, nirmatrelvir, stops protease from cutting viral products into smaller pieces.
- The second pill, ritonavir, protects nirmatrelvir from destruction by the body and allows it to keep working.
With a faulty polymerase or a large, unusable polyprotein, antiviral medications make it difficult for the coronavirus to replicate. If treated early enough, they can lessen the virus’s impact on the body.
The Future of COVID Antiviral Pills and Medications
Antiviral medications seem to have a bright future ahead of them.
COVID-19 antivirals are based on early research done on coronaviruses from the 2002-04 SARS-CoV and the 2012 MERS-CoV outbreaks. Current breakthroughs in this technology may pave the way for better pharmaceuticals in the future.
One half of Pfizer’s medication, ritonavir, currently treats many other viruses including HIV/AIDS.
Gilead Science is currently developing oral derivatives of remdesivir, another polymerase inhibitor currently only offered to inpatients in the United States.
More coronavirus antivirals are currently in the pipeline, offering a glimpse of control on the looming presence of COVID-19.
Author’s Note: The medical information in this article is an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. Please talk to your doctor before undergoing any treatment for COVID-19. If you become sick and believe you may have symptoms of COVID-19, please follow the CDC guidelines.
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