Every Vaccine and Treatment in Development for COVID-19
As the number of confirmed COVID-19 cases continues to skyrocket, healthcare researchers around the world are working tirelessly to discover new life-saving medical innovations.
The projects these companies are working on can be organized into three distinct groups:
- Diagnostics: Quickly and effectively detecting the disease in the first place
- Treatments: Alleviating symptoms so people who have disease experience milder symptoms, and lowering the overall mortality rate
- Vaccines: Preventing transmission by making the population immune to COVID-19
Today’s graphics provide an in-depth look at who’s in the innovation race to defeat the virus, and they come to us courtesy of Artis Ventures, a venture capital firm focused on life sciences and tech investments.
Editor’s note: R&D is moving fast on COVID-19, and the situation is quite fluid. While today’s post is believed to be an accurate snapshot of all innovations and developments listed by WHO and FDA as of March 30, 2020, it is possible that more data will become available.
Knowledge is Power
Testing rates during this pandemic have been a point of contention. Without widespread testing, it has been tough to accurately track the spread of the virus, as well as pin down important metrics such as infectiousness and mortality rates. Inexpensive test kits that offer quick results will be key to curbing the outbreak.
Here are the companies and institutions developing new tests for COVID-19:
The ultimate aim of companies like Abbott and BioFire Defense is to create a test that can produce accurate results in as little as a few minutes.
In the Trenches With Coronavirus
While the majority of people infected with COVID-19 only experience minor symptoms, the disease can cause severe issues in some cases – even resulting in death. Most of the forms of treatment being pursued fall into one of two categories:
- Treating respiratory symptoms – especially the inflammation that occurs in severe cases
- Antiviral growth – essentially stopping viruses from multiplying inside the human body
Here are the companies and institutions developing new treatment options for COVID-19:
A wide range of players are in the race to develop treatments related to COVID-19. Pharma and healthcare companies are in the mix, as well as universities and institutes.
One surprising name on the list is Fujifilm. The Japanese company’s stock recently shot up on the news that Avigan, a decades-old flu drug developed through Fujifilm’s healthcare subsidiary, might be effective at helping coronavirus patients recover. The Japanese government’s stockpile of the drug is reportedly enough to treat two million people.
The progress that is perhaps being watched the closest by the general public is the development of a COVID-19 vaccine.
Creating a safe vaccine for a new illness is no easy feat. Thankfully, rapid progress is being made for a variety of reasons, including China’s efforts to sequence the genetic material of Sars-CoV-2 and to share that information with research groups around the world.
Another factor contributing to the unprecedented speed of development is the fact that coronaviruses were already on the radar of health science researchers. Both SARS and MERS were caused by coronaviruses, and even though vaccines were shelved once those outbreaks were contained, learnings can still be applied to defeating COVID-19.
One of the most promising leads on a COVID-19 vaccine is mRNA-1273. This vaccine, developed by Moderna Therapeutics, is being developed with extreme urgency, skipping straight into human trials before it was even tested in animals. If all goes well with the trials currently underway in Washington State, the company hopes to have an early version of the vaccine ready by fall 2020. The earliest versions of the vaccine would be made available to at-risk groups such as healthcare workers.
Further down the pipeline are 15 types of subunit vaccines. This method of vaccination uses a fragment of a pathogen, typically a surface protein, to trigger an immune response, teaching the body’s immune system how to fight off the disease without actually introducing live pathogens.
No Clear Finish Line
Unfortunately, there is no silver bullet for solving this pandemic.
A likely scenario is that teams of researchers around the world will come up with solutions that will incrementally help stop the spread of the virus, mitigate symptoms for those infected, and help lower the overall death toll. As well, early solutions rushed to market will need to be refined over the coming months.
We can only hope that the hard lessons learned from fighting COVID-19 will help stop a future outbreak in its tracks before it becomes a pandemic. For now, those of us on the sideline can only do our best to flatten the curve.
The Biggest Ammonium Nitrate Explosions Since 2000
Ammonium nitrate is dangerous, and every few years, there’s a new explosion that causes widespread damage. These are some of the biggest ones.
The Biggest Ammonium Nitrate Explosions since 2000
This week, a massive explosion involving ammonium nitrate rocked the city of Beirut, sending shock waves through the media.
This recent tragedy is devastating, and unfortunately, it’s not the first time this dangerous chemical compound has caused widespread damage.
Today’s graphic outlines the biggest accidental ammonium nitrate explosions over the last 20 years.
A Brief Explanation of Ammonium Nitrate
Before getting into the details, first thing’s first—what is ammonium nitrate?
Ammonium nitrate is formed when ammonia gas is combined with liquid nitric acid. The chemical compound is widely used in agriculture as a fertilizer, but it’s also used in mining explosives. It’s highly combustible when combined with oils and other fuels, but not flammable on its own unless exposed to extremely high temperatures.
It’s actually relatively tough for a fire to cause an ammonium nitrate explosion—but that hasn’t stopped it from happening numerous times in the last few decades.
The Death Toll
Some explosions involving ammonium nitrate have been deadlier than others. Here’s a breakdown of the death toll from each blast:
*Note: death count in Beirut as of Aug 6, 2020. Casualty count expected to increase as more information comes available.
One of the deadliest explosions happened in Tianjin, China in 2015. A factory was storing flammable chemicals with ammonium nitrate, and because they weren’t being stored properly, one of the chemicals got too dry and caught fire. The blast killed 165 people and caused $1.1 billion dollars in damage.
In 2001, 14 years before the explosion in Tianjin, a factory exploded in Toulouse, France. The accident killed 30 people and injured 2,500. The power of the blast was equivalent to 20 to 40 tons of TNT, meaning that 40 to 80 tons of ammonium nitrate would have ignited.
In addition to factory explosions, there have been several transportation accidents involving ammonium nitrate. In 2007, a truck in Mexico blew up and killed over 57 people. Filled with explosives, the truck crashed into a pickup, caught fire, and detonated. The blast left a 60-foot long crater in its wake.
While there have been several ammonium nitrate accidents throughout history, the recent tragedy in Beirut is one of the largest accidental explosions ever recorded, with 157 deaths and 5,000 injuries and counting.
In terms of TNT equivalent, a measure used to gauge the impact of an explosion, it ranks in the top 10 of the largest accidental explosions in history:
Topping the list is yet another ammonium nitrate explosion, this time back in 1947.
Known to history as the Texas City Disaster, the port accident was one of the biggest non-nuclear explosions to occur in history. The explosion killed over 500 people and injured thousands. The impact from the blast was so intense, it created a 15-foot wave that crashed along the docks and caused flooding in the area.
A Resource With Trade-Offs
Despite being dangerous, ammonium nitrate is still a valuable resource. There’s been an increased demand for the chemical from North America’s agricultural sector, and because of this, ammonium nitrate’s market size is expected to see an increase of more than 3% by 2026.
Because of its increasing market size, it’s more important than ever for trade industries to enforce proper safety measures when storing and transporting ammonium nitrate. When safety regulations aren’t followed, accidents can happen—and as we saw this week, the aftermath can be devastating.
Visualizing the Power and Frequency of Earthquakes
Our planet is in a constant state of creation and destruction as the plates of the earth collide. This visualization looks at earthquake magnitude.
Visualizing the Power and Frequency of Earthquakes
The surface of our planet is in a constant state of creation and destruction as the plates of the Earth collide. It is this movement of the Earth’s crust that causes earthquakes, sending tremors throughout the world.
Today’s graphic is inspired by a classic USGS diagram that tracks the scale and frequency of earthquakes.
Earthquakes occur because the crust of the Earth is made up of several plates. The boundaries of these plates create faults that can run into one another.
Earthquakes describe both the mechanism that causes a sudden stress release along plate boundaries and also the ensuing ground shaking.
They occur when stress builds up along a tectonic fault. This stress causes the two surfaces of the fault, which had previously been stuck together due to friction, to suddenly move, or slide, releasing energy in the form of seismic waves.
Measuring an Earthquake’s Impact
There are three factors to assess the impact of Earthquakes – magnitude, energy, and intensity.
Magnitude is a number most commonly associated with the Richter scale, describing the size of an Earthquake on a scale from 0 to 10 – the latter of which is the maximum motion recorded by a seismograph. Each increase by one on the scale represents a tenfold increase in the amplitude. There are over a million tremors around the planet each year, but it’s not until an earthquake reaches a magnitude of 4 that humans can typically feel it.
Another way to measure the size of an earthquake is by how much energy it releases. The amount of energy radiated by an earthquake is a measure of the potential for damage to man-made structures.
An earthquake releases energy at various frequencies, and in order to calculate accurately, you have to include all frequencies of shaking for the entire event. Some research suggests technology could harness this energy for power generation.
Intensity describes the severity of an earthquake with a qualitative evaluation of its effects on the Earth’s surface and on the built environment. An earthquake may have a high magnitude but if a city or landscape experiences little damage, it can be said that the intensity is low. The Modified Mercalli Intensity Scale measures this intensity.
The World’s Largest Earthquakes by Magnitude
Prior to the development and use of seismographs, around 1900, scientists could only estimate magnitudes, based on historical reports of the extent and severity of damage.
|May 22, 1960||Valdivia, Chile||9.4-9.6|
|March 27, 1964||Prince William Sound, Alaska||9.2|
|Dec. 26, 2004||Indian Ocean, Sumatra, Indonesia||9.1|
|March 11, 2011||Pacific Ocean, Tohoku Region, Japan||9.1|
|July 8, 1730||Valparaiso, Chile||9.1-9.3 (est.)|
|Nov. 4, 1952||Kamchatka, Russia||9|
|Aug. 13, 1868||Arica, Chile||8.5-9.0 (est.)|
|January 26, 1700||Pacific Coast, Modern Day British Columbia||8.7-9.2 (est.)|
|April 2, 1762||Chittagong, Bangladesh||8.8 (est.)|
|Nov. 25, 1833||Sumatra Indonesia||8.8 (est.)|
Earthquakes are a fact of life on Earth and mark distinct moments in history. One would think given our knowledge of earthquakes, that humans would avoid these locations – however, the very faults of the Earth also create its greatest advantages.
Living with Your Faults
It’s extremely common to find human settlements along the fault lines where earthquakes occur most frequently. Some could say that this is because these decisions were made before a complete understanding of science enabled us to know the potential risks involved.
However, a recent scientific study reveals that there may be more to the pattern than previously thought. Tectonically active plates may have produced greater biodiversity, more food, and water for our human predecessors.
Certain landscape features formed by tectonic processes such as cliffs, river gorges, and sedimentary valleys create environments that support access to drinking water, shelter, and an abundant food supply.
This inherent problem reveals that humans are more connected to their environments than previously thought. It comes down to a question of how well humans can adapt their lifestyle and built environments to a dynamic planet.
Now let’s worry about the asteroids…
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