Every Vaccine and Treatment in Development for COVID-19
As the number of confirmed COVID-19 cases continues to skyrocket, healthcare researchers around the world are working tirelessly to discover new life-saving medical innovations.
The projects these companies are working on can be organized into three distinct groups:
- Diagnostics: Quickly and effectively detecting the disease in the first place
- Treatments: Alleviating symptoms so people who have disease experience milder symptoms, and lowering the overall mortality rate
- Vaccines: Preventing transmission by making the population immune to COVID-19
Today’s graphics provide an in-depth look at who’s in the innovation race to defeat the virus, and they come to us courtesy of Artis Ventures, a venture capital firm focused on life sciences and tech investments.
Editor’s note: R&D is moving fast on COVID-19, and the situation is quite fluid. While today’s post is believed to be an accurate snapshot of all innovations and developments listed by WHO and FDA as of March 30, 2020, it is possible that more data will become available.
Knowledge is Power
Testing rates during this pandemic have been a point of contention. Without widespread testing, it has been tough to accurately track the spread of the virus, as well as pin down important metrics such as infectiousness and mortality rates. Inexpensive test kits that offer quick results will be key to curbing the outbreak.
Here are the companies and institutions developing new tests for COVID-19:
The ultimate aim of companies like Abbott and BioFire Defense is to create a test that can produce accurate results in as little as a few minutes.
In the Trenches With Coronavirus
While the majority of people infected with COVID-19 only experience minor symptoms, the disease can cause severe issues in some cases – even resulting in death. Most of the forms of treatment being pursued fall into one of two categories:
- Treating respiratory symptoms – especially the inflammation that occurs in severe cases
- Antiviral growth – essentially stopping viruses from multiplying inside the human body
Here are the companies and institutions developing new treatment options for COVID-19:
A wide range of players are in the race to develop treatments related to COVID-19. Pharma and healthcare companies are in the mix, as well as universities and institutes.
One surprising name on the list is Fujifilm. The Japanese company’s stock recently shot up on the news that Avigan, a decades-old flu drug developed through Fujifilm’s healthcare subsidiary, might be effective at helping coronavirus patients recover. The Japanese government’s stockpile of the drug is reportedly enough to treat two million people.
The progress that is perhaps being watched the closest by the general public is the development of a COVID-19 vaccine.
Creating a safe vaccine for a new illness is no easy feat. Thankfully, rapid progress is being made for a variety of reasons, including China’s efforts to sequence the genetic material of Sars-CoV-2 and to share that information with research groups around the world.
Another factor contributing to the unprecedented speed of development is the fact that coronaviruses were already on the radar of health science researchers. Both SARS and MERS were caused by coronaviruses, and even though vaccines were shelved once those outbreaks were contained, learnings can still be applied to defeating COVID-19.
One of the most promising leads on a COVID-19 vaccine is mRNA-1273. This vaccine, developed by Moderna Therapeutics, is being developed with extreme urgency, skipping straight into human trials before it was even tested in animals. If all goes well with the trials currently underway in Washington State, the company hopes to have an early version of the vaccine ready by fall 2020. The earliest versions of the vaccine would be made available to at-risk groups such as healthcare workers.
Further down the pipeline are 15 types of subunit vaccines. This method of vaccination uses a fragment of a pathogen, typically a surface protein, to trigger an immune response, teaching the body’s immune system how to fight off the disease without actually introducing live pathogens.
No Clear Finish Line
Unfortunately, there is no silver bullet for solving this pandemic.
A likely scenario is that teams of researchers around the world will come up with solutions that will incrementally help stop the spread of the virus, mitigate symptoms for those infected, and help lower the overall death toll. As well, early solutions rushed to market will need to be refined over the coming months.
We can only hope that the hard lessons learned from fighting COVID-19 will help stop a future outbreak in its tracks before it becomes a pandemic. For now, those of us on the sideline can only do our best to flatten the curve.
Explainer: How Synthetic Biology is Redesigning Life
Synthetic biology (SynBio) is a field of science that involves engineering life for human benefit. Here’s an in-depth look at how it works.
Explainer: How Synthetic Biology is Redesigning Life
Synthetic biology (SynBio) is a field of science that involves engineering life for human benefit. It has the potential to reshape many facets of society—from the ways we produce food, to how we detect and cure diseases.
It’s a fast-growing field of science. In fact, by 2026, the SynBio market’s global revenue is expected to reach $34.5 billion, at a CAGR of 21.9%.
While this fascinating area of research is worth paying attention to, it might be daunting to wrap your head around—especially if you don’t come from a scientific background. With this in mind, here’s an introduction to synthetic biology, and how it works.
What is Synthetic Biology?
As we touched on in the introduction, SynBio is an area of scientific research that involves editing and redesigning the biological components, systems, and interactions that make up life. By doing this, SynBio can grant organisms new abilities that are beneficial to humans.
It’s similar to genetic engineering, however, it’s slightly more granular. While genetic engineering transfers ready-made genetic material between organisms, SynBio builds new genetic material from scratch.
SynBio has applications across a myriad of fields, with research covering everything from space exploration to drug discovery. Here’s a look at five of its real-world applications:
1. Medical Technologies
SynBio has a wide range of medical applications, including drug discovery, antibody production, and vaccine innovation (it’s been key in the fight against COVID-19). It also plays a significant role in “living drug” development, which is the use of living microbes to treat chronic or severe illnesses.
2. Sustainable Energies
Biofuel, which is renewable energy that’s derived from living matter, could replace petroleum and diesel in the near future—and synthetic biology technology is helping develop fermentation processes that will produce biofuel more efficiently.
Bioremediation uses living organisms to restore polluted sites to their original condition. This field uses SynBio to try and make the decontamination process more efficient, and to expand the list of contaminants that bioremediation can target.
4. Food and Agriculture
SynBio plays a significant role in cellular agriculture, which is the production of agricultural products directly from cells rather than livestock or plants. These modified foods might have higher nutritional value, or might be void of allergens. For instance, this can be used to make plant-based burgers taste more like meat.
5. Space Systems and Exploration
Synthetic biology and 3-D printing have huge potential to sustain life during space exploration. Using SynBio technology, cells and bacteria could be modified to produce a myriad of materials—from plastic to medicine, and even food—and astronauts could print these synthetically engineered materials on-demand while in space.
Zooming in: the Science Behind Synthetic Biology
Now that we’ve touched on SynBio’s use in a wide range of industries, let’s dive into the science behind it. In order to understand the mechanics of SynBio, it’s important to explore the relationship between DNA and protein production.
Proteins are the drivers of life in a cell—they’re responsible for carrying out all of life’s functions. They are created through a process called protein synthesis, which relies heavily on DNA. Why is DNA so important in protein production? Because it houses all the information a cell needs for protein synthesis.
Once a protein is formed, it embarks on a complex journey throughout the cell, interacting with a number of other proteins and cellular components to perform functions needed for the cell’s survival.
This process of protein production and cellular interaction is an example of a biological system. And it’s this biological system that synthetic biologists investigate, and try to manipulate.
The Five Main Areas of Research
After combing through the literature, we identified five major areas of SynBio research:
- In silico Synthetic Biology
Meaning “via computer”, this area of SynBio research uses computational simulations to design and predict new biological systems. It’s like using a drawing board before starting a project.
- “Unnatural” Molecular Biology
An area of research focused on altering the smallest unit of DNA—nucleotides.
This area of research deals with larger segments of DNA like genes or chromosomes, and sometimes other cell components that interact with DNA. It aims to create new proteins or protein systems and is the most popular area of SynBio research.
- Synthetic Genomics
Focused on altering and manipulating whole genomes (which is the complete set of a cell’s DNA).
- Protocell Synthetic Biology
This field of research aims to construct whole cells. This is a step towards creating organisms that are entirely synthetic
While early research in SynBio struggled to finish real-world projects, innovation in this field has ramped up quickly in the last decade.
Synthetic biology products are becoming increasingly more pervasive in everyday life—so much so that by 2030, some scientists believe most people will have eaten, worn, or used something created through synthetic biology.
Global Stars: The Most Innovative Countries, Ranked by Income Group
From Switzerland and China to Vietnam and Tanzania — here are the world’s most innovative countries, taking income per capita into account.
The Most Innovative Countries, Ranked by Income Group
Innovation can be instrumental to the success of economies, at macro and micro scales. While investment provides powerful fuel for innovation—the relationship isn’t always straightforward.
The 2020 ranking from the World Intellectual Property Organization (WIPO) reveals just that.
The above map breaks down the most innovative countries in each World Bank income group, based on data from WIPO’s Global Innovation Index (GII), which evaluates nations across 80 innovation indicators like research and development (R&D), venture capital, and high-tech production.
While wealthier nations continue to lead global innovation, the GII also shows that middle-income countries—particularly in Asia—are making impressive strides.
The economic and regulatory spheres within countries can have an enormous impact on their level of innovation—and vice versa, as innovation in turn becomes an economic driver, stimulating further investment.
The positive feedback loop between investment and innovation results in the success of some of the top countries in the table below, which shows the three most innovative countries in each income group.
|Income Group||Group Rank||Country (Overall Rank)|
|High||1||🇨🇭 Switzerland (#1)|
|High||2||🇸🇪 Sweden (#2)|
|High||3||🇺🇸 United States of America (#3)|
|Upper Middle||1||🇨🇳 China (#14)|
|Upper Middle||2||🇲🇾 Malaysia (#33)|
|Upper Middle||3||🇧🇬 Bulgaria (#37)|
|Lower Middle||1||🇻🇳 Vietnam (#42)|
|Lower Middle||2||🇺🇦 Ukraine (#45)|
|Lower Middle||3||🇮🇳 India (#48)|
|Low||1||🇹🇿 Tanzania (#88)|
|Low||2||🇷🇼 Rwanda (#91)|
|Low||3||🇲🇼 Malawi (#111)|
Switzerland, Sweden, and the U.S. are the top three in the high-income group. Considering that Switzerland has the second-highest GDP per capita globally, it is not a surprise leader on this list.
Upper middle-income countries are led by China, Malaysia, and Bulgaria. Note that China far surpasses other nations in the upper-middle-income group ranking, reaching 14th spot overall in 2020. Others in the income group only appear in the overall ranking after 30th place.
Below are several income group leaders, and some of their key areas of output:
- Switzerland: First in Knowledge Creation, second in Global Brand Value
- U.S.: First in Entertainment and Media, Computer Software Spending, Intellectual Property Receipts
- China: First in Patents Registered
- Vietnam: Second in High-Technology Net Exports
- India: First in Information and Communication Technology Services Exports
- Tanzania: 23rd in Printing and Other Media
Shining a Light on Global Innovators
Since 2011, Switzerland has led the world in innovation according to this index, and the top five countries have seen few changes in recent years.
Sweden regained second place in 2019 and the U.S. moved into third—positions they maintain in 2020. The Netherlands entered the top two in 2018 and now sits at fifth.
Here’s how the overall ranking shakes out:
|3||United States of America||60.6||High|
|11||Hong Kong, China||54.2||High|
|34||United Arab Emiratesx||42.4||High|
|42||Viet Nam||37.1||Lower Middle|
|47||Russian Federation||35.6||Upper Middle|
|56||Costa Rica||33.5||Upper Middle|
|57||North Macedonia||33.4||Upper Middle|
|59||Republic of Moldova||33.0||Lower Middle|
|60||South Africa||32.7||Upper Middle|
|67||Iran (Islamic Republic of)||30.9||High|
|74||Bosnia and Herzegovina||29.0||Upper Middle|
|88||United Republic of Tanzania||25.6||Lower I|
|90||Dominican Republic||25.1||Upper Middle|
|92||El Salvador||24.9||Lower Middle|
|98||Trinidad and Tobago||24.1||High|
|100||Cabo Verde||23.9||Lower Middle|
|101||Sri Lanka||23.8||Upper Middle|
|105||Bolivia (Plurinational State of)||22.4||Lower Middle|
|112||Côte d’Ivoire||21.2||Lower Middle|
|113||Lao People’s Democratic Republic||20.7||Lower Middle|
|118||Burkina Faso||20.0||Lower I|
Nordic countries like Sweden, Denmark, and Finland continue their strong showing across innovation factors—like Knowledge Creation, Global Brand Value, Environmental Performance, and Intellectual Property Receipts—leading to their continued presence atop global innovators.
But the nations making the biggest moves in GII ranking are found in Asia.
China, Vietnam, India, and the Philippines have risen the most of all countries, with all four now in the top 50. China broke into the top 15 in 2019 and remains the only middle-income economy in the top 30.
In 2020, South Korea became the second Asian economy to enter the top 10, after Singapore. As the first Asian country to move into the global top five, Singapore joined the leaders in 2018, and now sits at 8th place.
In another first for 2020, India has now broken into the top 50.
Innovation Input & Output: The Overachievers
While annual rankings like these confirm the importance of a robust economy and innovation investment, variations in the relationship between input and output are not uncommon.
The correlation between wealth and innovation isn’t always straightforward, and neither is the connection between innovation input and output.
Below is an overview of the GII inputs and outputs, as well as several of the world’s overall leaders in each pillar.
Input variables can be characterized as factors that foster innovation—everything from the quality of a country’s university institutions to its levels of ecological sustainability.
|Input Pillars||Input Examples||Input Leaders|
Human Capital & Research
Venture Capital Deals
7. Hong Kong, China
10. South Korea
Output factors include innovation indicators like the creation of new businesses, and even the number of Wikipedia edits made per million people.
|Output Pillars||Output Types||Output Leaders|
|Knowledge & Technology|
Creative goods and services
National feature films
Entertainment and media
3. United Kingdom
10. South Korea
Countries with impressive innovation outputs compared to input levels include:
- China: 26th in inputs, but sixth in overall innovation outputs
- Netherlands: 11th in innovation input, but fourth across outputs
- Thailand: 48th in overall input, first in business R&D
- Malaysia: 34th in overall input, first in high-tech net exports
Innovation Fuel Reductions Up Ahead?
Although financial markets have ignited, the economy as a whole has not fared well since lockdowns began. This begs the question of whether a steep decline in innovation capital will follow.
In response to the 2020 pandemic, will spending on R&D echo the 2009 recession and aftermath of 9/11? Will venture capital flows continue to decline more than they have since 2018?
Because innovation is so entwined with the economic growth strategies of companies and nations alike, the WIPO notes that the potential decline may not be as severe as historical trends might suggest.
No Stopping Human Innovation
Thankfully, innovation opportunities are not solely contingent on the level of capital infused during any given year. Instead, the cumulative results of continuous innovation stimuli may be enough to maintain growth, while strategic cash reserves are put to use.
What the GII ranking shows is that inputs don’t always equal outputs—and that innovative strides can be made with even modest levels of capital flow.
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